职    称

  讲师

科研方向

  植物和病毒互作，抗病毒药剂研究 

招生专业

  植物保护（植物病理学） 

联系方式

  kaiqiang1991@sdau.edu.cn

个人简介

郝凯强，男，汉族，山东省青州人，农学博士。近年来，发表以Chemical Engineering Journal，Journal of Nanobiotechnology，International Journal of Molecular Sciences为代表的科技论文13余篇。

教学背景及工作经历

2024.03-至      今：海洋之神590线路检测中心\讲师

2019.09-2023.12：沈阳农业大学\海洋之神590线路检测中心\植物病理学专业\博士

2015.09-2017.07：云南农业大学\海洋之神590线路检测中心\农药专业\硕士

2010.09-2014.07：海洋之神590线路检测中心\海洋之神590线路检测中心\植物保护学专业\学士

教学工作

主要承担本科生《普通植物病理学》、《普通植物病理学实验》、《植物保护概论》。

研究方向

1. 玉米褪绿斑驳病毒和植物互作机制；

2. 新型抗病毒纳米药剂的创制和应用。

科研项目

1. 国家自然科学基金青年基金项目：miR827调控的磷平衡在玉米抗甘蔗花叶病毒中的作用机制研究，资助年限：2019.1-2021.12，参与人；

2. 中国烟草总公司云南省公司科技计划项目-重大项目，利用TOM2A基因创制K326抗病毒新品系，资助年限：2022.01-2024.12，参与人；

3. 山东省重点研发计划项目：玉米重大病害成灾机制及防控技术研究，资助年限：2023.01-2025.12，课题一参与人。

代表性科研成果

1. Kaiqiang Hao, Xinran Gao, Miaoren Yang, Zhiping Wang, Mengnan An, He Liu, Zihao Xia, and Yuanhua Wu. A nanomaterial for the delivery of dsRNA as a strategy to alleviate viral infections in maize. Chemical Engineering Journal 488:150923 (2024). doi.org/10.1016/j.cej.2024.150923 (SCI, IF=13.3，1区)；

2. Kaiqiang Hao, Miaoren Yang, Yakun Cui, Zhiyuan Jiao, Xinran Gao, Zhichao Du, Zhiping Wang, Mengnan An, Zihao Xia, and Yuanhua Wu. Transcriptomic and functional analyses reveal the different roles of Vitamins C, E, and K in regulating viral infections in maize. International Journal of Molecular Sciences 24(9) (2023). doi.org/10.3390/ijms24098012 (SCI, IF=4.9，2区)；

3. Jie Wang, Kaiqiang Hao, Fangfei Yu, Lili Shen, Fenglong Wang, Jinguang Yang, and Chenyu Su. Field application of nanoliposomes delivered quercetin by inhibiting specific hsp70 gene expression against plant virus disease. Journal of Nanobiotechnology 20: 1-16 (2022). doi.org/10.1186/s12951-021-01223-6 (SCI, IF=10.6，1区)；

4. Kaiqiang Hao, Beisen Lin#, Fuzhao Nian#, Xi Gao, Zhong Wei, Gang Luo, Yachun Lu, Mingxian Lan, Jinguang Yang, and Guoxing Wu. RNA-seq analysis of the response of plant-pathogenic oomycete Phytophthora parasitica to the fungicide dimethomorph. Revista Argentina de Microbiologia 51(3):268-77 (2019). doi.org/10.1016/j.ram.2018.08.007 (SCI, IF=1.8，4区)；

5. Xinran Gao, Kaiqiang Hao, Zhichao Du, Sijia Zhang, Zhiping Wang, Mengnan An, Zihao Xia, and Yuanhua Wu. Identification of ceRNA-vsiRNA-mRNA network for exploring the mechanism underlying pathogenesis of sugarcane mosaic virus in resistant and susceptible maize inbred lines. Phytopathology Research 5(1):60 (2023). doi.org/10.1186/s42483-023-00216-7 (SCI, IF=3.2，2区)；

6. Xinran Gao, Kaiqiang Hao, Zhichao Du, Sijia Zhang, Jinxiu Guo, Jian Li, Zhiping Wang, Mengnan An, Zihao Xia, and Yuanhua Wu. Whole-transcriptome characterization and functional analysis of lncRNA-miRNA-mRNA regulatory networks responsive to sugarcane mosaic virus in maize resistant and susceptible inbred lines. International Journal of Biological Macromolecules 257:128685 (2024). doi.org/10.1016/j.ijbiomac.2023.128685 (SCI, IF=7.7，1区)；

7. Yubing Jiao, Xiuxiang Zhao, Kaiqiang Hao, Xinran Gao, Dan Xing, Zhiping Wang, Mengnan An, Zihao Xia, and Yuanhua Wu. Characterization of small interfering RNAs derived from pepper mild mottle virus in infected pepper plants by high-throughput sequencing. Virus Research 307:198607 (2022). doi.org/10.1016/j.virusres.2021.198607 (SCI, IF=2.5，4区)；

8. Hangjun Sun, Lili Shen, Yuanxia Qin, Xiaowei Liu, Kaiqiang Hao, Ying Li, Jie Wang, Jinguang Yang, and Fenglong Wang. CLC-Nt1 affects potato virus Y infection via regulation of endoplasmic reticulum luminal Ph. New Phytologist 220(2):539-52 (2018). doi.org/10.1111/nph.15310 (SCI, IF=8.3，1区)；

9. Zihao Xia, Sijia Zhang, Huiyan Guo, Xinran Gao, Kaiqiang Hao, Xue Dong, Jinxiu Guo, Jian Li, Zhiping Wang, Mengnan An, Yuanhua Wu, and Xueping Zhou. N6-methyladenosine RNA modification regulates maize resistance to maize chlorotic mottle virus infection. Journal of Agricultural and Food Chemistry. (2024). https://doi.org/10.1021/acs.jafc.4c04832 (SCI, IF=5.7，1区);

10. Xinran Gao, Yuan Chen, Xuecong Luo, Zhichao Du, Kaiqiang Hao, Mengnan An, Zihao Xia, and Yuanhua Wu. Recombinase polymerase amplification assay for simultaneous detection of maize chlorotic mottle virus and sugarcane mosaic virus in maize. ACS Omega 6(28):18008-13 (2021). doi.org/10.1021/acsomega.1c01767 (SCI, IF=3.7，3区)；

11. Yuan Chen, Shiping Guo, Lianqiang Jiang, Fangfang Yan, Kaiqiang Hao, Zhiping Wang, Mengnan An, Zihao Xia, Fangfang Li, and Xueping Zhou. Molecular characterization and pathogenicity of a novel monopartite geminivirus infecting tobacco in China. Virology 110061 (2024). doi.org/10.1016/j.virol.2024.110061 (SCI, IF=3.7，3区)；

12. Yuanxia Qin, Jie Wang, Fenglong Wang, Lili Shen, Haixiang Zhou, Hangjun Sun, Kaiqiang Hao, Liyun Song, Zhicheng Zhou, and Chaoqun Zhang. Purification and characterization of a secretory alkaline metalloprotease with highly potent antiviral activity from Serratia marcescens strain S3. Journal of Agricultural and Food Chemistry 67(11):3168-78 (2019). doi.org/10.1021/acs.jafc.8b06909 (SCI, IF=5.7，1区)；

13. Liyun Song, Jie Wang, Haiyan Jia, Ali Kamran, Yuanxia Qin, Yingjie Liu, Kaiqiang Hao, Fei Han, Chaoqun Zhang, and Bin Li. Identification and functional characterization of NbMLP28, a novel MLP-like protein 28 enhancing potato virus Y resistance in Nicotiana benthamiana. BMC microbiology 20:1-14 (2020). doi.org/10.1186/s12866-020-01725-7 (SCI, IF=4，2区)；

14.  实用新型专利：郝凯强,兰明先,吴国星,何霞红,秦小萍，高熹.(2017-02-15).CN205946941U.